MOTS-c

MOTS-c – Research-Grade Mitochondrial-Derived Peptide (16 Amino Acids)

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a synthetic research analog of an endogenous mitochondrial-derived peptide consisting of 16 amino acid residues. Encoded within mitochondrial DNA, MOTS-c is structurally distinct from nuclear-encoded peptides and proteins. In laboratory research settings, MOTS-c is utilized as a reference material for studying mitochondrial signaling models, peptide-mediated metabolic pathway interactions, and sequence-specific biochemical behavior associated with mitochondrial-derived peptides.

Due to its short, linear structure and absence of disulfide bonds, MOTS-c exhibits physicochemical properties that differ from larger mitochondrial proteins and multi-domain signaling molecules. This simplicity allows researchers to examine peptide stability, intracellular interaction models, and degradation dynamics in vitro without confounding structural complexity. Its defined amino acid sequence and consistent synthetic profile support controlled use in mechanistic assays, comparative peptide studies, and exploratory biochemical research conducted under controlled laboratory conditions.